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March 1966

Anabolic Steroids in Cystic Fibrosis of the Pancreas

Author Affiliations

From the Department of Pediatrics, University of Maryland Medical School, Baltimore.

Am J Dis Child. 1966;111(3):272-277. doi:10.1001/archpedi.1966.02090060082007

MANY CHILDREN with cystic fibrosis show malnutrition of increasing severity as they grow older.1 As we had observed that the development of severe anorexia is frequently a terminal event in fibrocystic disease, we tried, as a last resort, "artificial" stimulation of appetite by an anabolic steroid in large dosages in a terminal case. The dramatic result prompted us to extend the observation to other advanced cases. This report deals with six patients treated with large dosages of anabolic steroid, estrogen, or progestational compounds.

Report of Cases  Case 1.—A case of cystic fibrosis was diagnosed for this girl at the age of 6 years when she had bilateral emphysema and perihilar infiltrations by chest x-ray, negative stool trypsin, and a sweat chloride of 71 mEq/liter.The course of her disease fluctuated with recurrent episodes of pneumonia, appetite failure, weight loss, inanition, and psychic depression. As may be seen from her

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