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April 1966

Neonatal Hyperbilirubinemia and Renal Vein Thrombosis: Occurrence in a Newborn Infant of a Diabetic Mother

Author Affiliations

From the departments of pediatrics and surgery, Kansas University Medical Center, Kansas City, Kan.

Am J Dis Child. 1966;111(4):433-436. doi:10.1001/archpedi.1966.02090070131022

IN INFANTS of diabetic mothers hyperbilirubinemia has frequently been observed.1,2 The mechanism of formation of the unconjugated bilirubin remains obscure.3 Although renal vein thrombosis has most often been described in association with diarrhea and dehydration,4-5 several authors have described this phenomenon as another of the complications of infants of diabetic mothers.6-7 Regardless of the underlying pathological condition, when renal vein thrombosis has occurred, the mortality rate has been high.8-9 The present report is related to the methodology involved in early diagnosis and surgical therapy of an infant of a diabetic mother with hyperbilirubinemia and renal vein thrombosis.

Report of a Case  A white boy was born after 40 weeks of gestation by elective cesarean section to a 33-year-old "brittle" diabetic mother with a history of vaginal bleeding at 32 weeks. His birth weight was 8 lb 8 oz (3,855 gm). Initially he was lethargic. Because