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June 1966

McCune-Albright Syndrome With Hyperthyroidism

Author Affiliations

From the Department of Pediatrics, Northwestern University Medical School (Dr. Steiner), and Department of Pediatrics (Dr. Lulejian) and Division of Endocrinology (Drs. Zangeneh and Steiner), Children's Memorial Hospital, Chicago. Dr. Zangeneh is presently with the Department of Pediatric Endocrinology, University of Washington, Seattle.

Am J Dis Child. 1966;111(6):644-648. doi:10.1001/archpedi.1966.02090090116013

COEXISTENCE of endocrinopathies in polyostotic fibrous dysplasia has been well established.1 In girls, the association of skeletal fibrous dysplasia, sex precocity, and skin pigmentation has been accorded the eponym of McCune-Albright syndrome.2,3 In boys, however, concomitant sex precocity has been rarely noted and evidence of hyperthyroidism has been reported only infrequently.1,4-7 This communication is a report of a white boy with polyostotic fibrous dysplasia, skin pigmentation, and hyperthyroidism. A summary of nine similar cases in the English literature is presented in table form.

Report of a Case  A 311/12-year-old white boy was referred to the Children's Memorial Hospital on Nov 3, 1965, because of enlargement of the thyroid and roentgen findings of polyostotic fibrous dysplasia. He was the product of an uncomplicated 38-week gestation and delivery, and birth weight of 7 lb (3,175 gm). He was well until the summer prior to this hospitalization when a fall

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