[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.204.202.44. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
July 1966

Growth and Bone Characteristics of Phenylketonurics: Comparative Analysis of Treated and Untreated Phenylketonuric Children

Author Affiliations

MINNEAPOLIS
From the departments of pediatrics (Drs. Fisch and Gravem) and radiology (Dr. Feinberg), University of Minnesota, Minneapolis.

Am J Dis Child. 1966;112(1):3-10. doi:10.1001/archpedi.1966.02090100039002
Abstract

AFTER MANAGING and studying a group of patients in the Phenylketonuric Clinic at the University of Minnesota Hospitals, clinical, statistical, and radiographical data have been collected, classified, and evaluated. The purpose of this report is (1) to discuss some of the growth patterns characteristic of phenylketonuric children on a restricted diet, (2) to compare their growth and bone age with those of phenylketonuric children on an unrestricted diet, and (3) to suggest a practical application gleaned from these results.

One of the most restricted diets prescribed and supervised by physicians is the low-phenylalanine diet for phenylketonuric patients. Phenylalanine-intake restriction can result in several complications such as cutaneous lesions,1,2 hypoglycemia,3 bone changes,4,5 megaloblastic anemia,6 and death.3 Brimblecombe et al1 and Moncrieff et al2 found that infants were temporarily unable to gain in weight after their phenylalanine intake had been restricted. Centerwall et al7

×