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July 1966

Optic Neuritis and Chloramphenicol

Author Affiliations

From the departments of pediatrics and ophthalmology, Wayne State University, and Children's Hospital of Michigan, Detroit.

Am J Dis Child. 1966;112(1):46-48. doi:10.1001/archpedi.1966.02090100082009

OPTIC NEURITIS has been associated with chloramphenicol therapy in both adults and children.1-9 It is our purpose to report two additional cases occurring in children with cystic fibrosis, who were treated with large doses of chloramphenicol over a prolonged period of time.

Report of Cases  Case 1.—This 5-year-old white girl is one of apparently identical twins with moderately advanced cystic fibrosis. The diagnosis was established elsewhere on the basis of symptoms which began at the age of 2 months. The diagnosis was confirmed here at the age of 3 years on the basis of the clinical picture, the chest x-ray, and a sweat test (chloride greater than 100 mEq/liter).Treatment included postural drainage, nighttime mist tent, pancreatic extract, vitamins, and sodium oxacillin at various times. At the age of 4½ years (July 1964), because of progression of her respiratory disease, she was given chloramphenicol in a dose of 750

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