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August 1966

Zinc Glucagon in Idiopathic Hypoglycemia of Infancy: Efficacy in Long-Term Control

Author Affiliations

From the Department of Pediatrics, University of Wisconsin Medical Center, Madison, Wis.

Am J Dis Child. 1966;112(2):107-111. doi:10.1001/archpedi.1966.02090110051002

AN INADEQUATE circulating glucose concentration can be the cause of irreparable damage to the central nervous system.1-3 This effect is most devastating during the time of rapid brain development in infancy, when 90% of the children with idiopathic infantile hypoglycemia begin to have symptoms.2 Thus, early recognition of hypoglycemia and maintenance of adequate blood glucose levels during infancy and childhood in these patients are of critical importance. Furthermore, these children will eventually experience spontaneous amelioration or complete remission of their metabolic disturbance.1

No form of long-term management of idiopathic hypoglycemia has been uniformly effective in all cases.3 These patients have been consistently responsive to the hyperglycemic effect of aqueous glucagon injection.3-8 Its effect is short lived, however, rendering it impractical for long-term management. The use of the long-acting zinc glucagon preparation in controlling infantile idiopathic hypoglycemia was initially reported in 1963.9 The present report,

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