OTHER investigators,1-6 utilizing various techniques, have attempted to determine objectively the response of cough to antitussive medication. Volunteer adult patients were used almost exclusively in those studies. The techniques employed have consisted of induction of cough by artificial means, such as successive inhalations of an irritant aerosol, and of assay of antitussive activity of cough medications based on reduction in number of coughs provoked by the irritant. The irritant usually was citric acid or acetylcholine. While the data obtained gave a valid indication of a cough-suppressing effect, experimental production of cough by chemical or mechanical irritants is subject to certain limitations and criticisms. First, the healthy volunteer after repeated exposure develops a tolerance to the irritant, especially when the latter is citric acid. Second, the frequency and intensity of artificially induced cough vary with the concentration of the irritant and the interval between challenges. Third, the artificially induced cough
REECE CA, CHERRY AC, REECE T, HATCHER TB, DIEHL AM. Tape Recorder for Evaluation of Coughs in ChildrenEvaluation of Antitussive Agents. Am J Dis Child. 1966;112(2):124–128. doi:10.1001/archpedi.1966.02090110068005
Customize your JAMA Network experience by selecting one or more topics from the list below.