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August 1966

Acrodynia—Postmortem of a Disease

Author Affiliations

From the Children's Hospital Research Foundation and the Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati.

Am J Dis Child. 1966;112(2):146-156. doi:10.1001/archpedi.1966.02090110090009

ON Jan 17, 1920, Dr. Joseph B. Bilderback of Portland presented to the North Pacific Pediatric Society meeting in Seattle a paper entitled "A Group of Cases of Unknown Etiology and Diagnosis."1 The report dealt with ten children "who presented symptoms somewhat out of the ordinary and yet all so much alike that they could safely be called the same condition." The disease was characterized by profuse sweating and swollen red feet and hands which were cold, clammy, desquamating, and painfully sensitive to touch. Sometimes there was a rash on the body, legs, and arms. There was progressive weight loss, marked weakness, and apathy. The patellar reflexes were absent and the children did not want to sit up. Those who had walked before, gave up standing and walking. Two children had profuse salivation, reddened, swollen gums, were losing several teeth, and had "a great deal of dead bone." There