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September 1966

Hyponatremia and Vincristine Therapy: Syndrome Possibly Resulting From Inappropriate Antidiuretic Hormone Secretion

Author Affiliations

From the Department of Pediatrics, University of Southern California, and the Division of Hematology, Childrens Hospital of Los Angeles.

Am J Dis Child. 1966;112(3):256-259. doi:10.1001/archpedi.1966.02090120124015

SCHWARTZ et al1 in 1957 described two patients with bronchogenic carcinoma who exhibited hyponatremia and excessive renal sodium loss. Metabolic studies in these patients gave results similar to those described in normal subjects receiving vasopressin (Pitressin). This syndrome has also been described in patients with tuberculosis, meningitis,2 myxedema,3 acute intermittent porphyria,4 and various diseases involving the central nervous system (CNS) (tumor, trauma, and vascular disease5,6). The syndrome was attributed to inappropriate secretion of antidiuretic hormone (ADH).1

The purpose of this report is to describe a patient who manifested hyponatremia and excessive renal sodium loss in conjunction with vincristine therapy for a rhabdomyosarcoma of the spermatic cord.

Report of a Case  The patient was first seen at the Childrens Hospital of Los Angeles in February 1965, at the age of 11 months because of a scrotal mass. The mass was first detected at the age

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