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November 1966

Skeletal Muscle Lesions in Congenital Rubella Syndrome

Author Affiliations

From the Division of Neurology and the Department of Pathologic Anatomy, Children's Hospital of Philadelphia, and the departments of neurology and pathology, School of Medicine, University of Pennsylvania.

Am J Dis Child. 1966;112(5):427-428. doi:10.1001/archpedi.1966.02090140099008

A DESCRIPTION of the pathology of skeletal muscle in the congenital rubella syndrome (CRS) and the possible significance of the findings form the basis of this paper. Except for a report of cellular and nuclear changes in fetal skeletal muscle1 obtained from products of abortion from women who had rubella during early pregnancy, no reference to lesions of this tissue in infants with CRS could be found among the accounts of the pathology of this entity.

Material  Sections of psoas muscle were obtained during autopsies performed at the Children's Hospital of Philadelphia on four infants with verified CRS.Three of the babies (cases 1 to 3) survived less than three months; these two girls and one boy were chronically ill with cardiorespiratory or other manifestations of the syndrome. The fourth (Case 4) died at 11½ months of age, and at that time weighed only 200 gm (7 oz) more