THE TERM "mixed gonadal dysgenesis" was first applied in 1964 by Sohval to a condition characterized by ambiguous genitalia with a testis on one side and a rudimentary or absent gonad on the other. Bergada et al1 used the term "asymmetrical gonadal dysgenesis" for a similar picture and considered the condition a variant of male pseudohermaphroditism. We recently have studied two patients with comparable findings.
Report of Cases
Case 1.—This patient was first seen when she was 11 years old. Ambiguous genitalia had been noted at birth. Although the question of her true sex had never been solved, the child had been reared as a girl.Clinical and radiological examinations revealed no malformations other than those of the ambiguous external genitalia: the urethral meatus opened at the base of an hypospadic phallus; the labioscrotal folds were fused; a gonad was palpable on the right side while the left gonad
JOSSO N, DE GROUCHY J, NEZELOF C, FREZAL J, JAMMET M, LAMY M. Mixed Gonadal Dysgenesis: Two Additional Pediatric Cases. Am J Dis Child. 1966;112(6):531–535. doi:10.1001/archpedi.1966.02090150075004
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: