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Article
April 1967

Study of an Anabolic Steroid: Certain Effects of Oxymetholone on Small Children

Author Affiliations

Oklahoma City
From the Department of Pediatrics, Children's Memorial Hospital, University of Oklahoma Medical Center, Oklahoma City.

Am J Dis Child. 1967;113(4):422-430. doi:10.1001/archpedi.1967.02090190068004
Abstract

GROWTH and weight gain of children may be promoted by the administration of anabolic steroids. Side effects encountered in using these drugs may include: (1) acceleration of skeletal maturation in excess of linear growth, (2) undesirable androgenic effects, and (3) others.1 A desirable anabolic steroid for use in children would be one with a high ratio of growth and weight gain effect to skeletal maturation and androgenic effect. Several reports on the utilization of these agents in children are available,1-9 the ratio of growth and weight gain effect to skeletal maturation and androgenic effect varied from drug to drug. Other undesirable side effects were generally minimal and reversible.

The present study was undertaken to evaluate certain effects of oxymetholone, another anabolic steriod, on growth-retarded, underweight children. Oxymetholone is a partially synthetic steriod, 17-β-hydroxy-2-hydroxymethylene-17-α-methyl-3-androstanone. Previous work indicated that oxymetholone may be useful as an anabolic agent in children.10-17

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