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June 1967

The Exfoliative Source of Abnormal Cells: In Urine Sediment of Patients With Measles

Author Affiliations

From the Department of Pathology, The Children's Hospital, Akron, Ohio, and Western Reserve University, Cleveland. Dr. Lipsey is a fellow of the Department of Pathology.

Am J Dis Child. 1967;113(6):677-682. doi:10.1001/archpedi.1967.02090210091009

IN RECENT years it has been appreciated that abnormal cells are excreted into the urine during the course of certain viral illnesses.1-9 In some instances the presence of such cells has been associated with viruria.5 In addition to the well-known cytologic changes in the urine in cytomegalic inclusion disease, cellular abnormalities have been described with a number of the common viral exanthems1-4,6-9 and following vaccination with live viruses.2,8,10 By far the most dramatic cytologic changes are present during measles. This infection is associated with the appearance of numerous cells containing large eosinophilic, cytoplasmic inclusions (Fig 1) as well as syncytial multinucleated cells of the Warthin-Finkeldey type2 (Fig 2).

Until recently the question has persisted as to whether these cellular alterations in urine sediment represent specific cytopathic effects of virus.9,10 The appearance of these cytologic changes coincides with the presence of measles virus in the

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