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October 1967

Studies in Hypoglycemia of Infancy and Childhood: Diagnosis and Treatment

Author Affiliations

Nashville, Tenn
From the Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, and Vanderbilt University Medical School, Nashville, Tenn. Dr. Antony was formerly a US Public Health Service Trainee in Endocrinology and Metabolism at the University of North Carolina under training grant AM5330. He is currently at the University of Vermont School of Medicine, Burlington, Vermont. Dr. Underwood was formerly Chief Resident in Pediatrics, Vanderbilt University Medical School. He is now a US Public Health Service Trainee in Endocrinology and Metabolism at the University of North Carolina. Dr. Van Wyk is a US Public Health Service Career Research Awardee on grant 5-K6-AM-14, 115.

Am J Dis Child. 1967;114(4):345-369. doi:10.1001/archpedi.1967.02090250043001

ALTHOUGH elaborate classifications have been proposed, most children who develop hypoglycemia after the newborn period still fall into the group vaguely termed "idiopathic hypoglycemia of infancy and childhood." This study was undertaken to determine whether the clinical features and the responses to standard tests of blood sugar regulation are sufficiently distinctive to discriminate "idiopathic" cases from those of known etiology or provide any clues to possible etiologic mechanisms within the idiopathic group. This was done by analyzing the findings in a group of infants and children with idiopathic hypoglycemia and contrasting them with those in selected cases of hypoglycemia caused by hypopituitarism or insulinoma.

A further objective of this study was to resolve some of the conflicting recommendations for the management of these patients. This report is based on the records of selected children admitted with the diagnosis of hypoglycemia to the North Carolina Memorial Hospital and Vanderbilt University Hospital.

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