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November 1967

The Development of Immunological Capacity in Phylogenetic Perspective

Author Affiliations

From the Pediatric Research Laboratory Variety Club Heart Hospital and Department of Microbiology, University of Minnesota, Minneapolis. Dr. Good is an American Legion Memorial Heart Research Professor. Dr. Finstad is a research fellow, US Public Health Service grant 9T1-AI292. Dr. Gewurz is a postdoctoral fellow now at the National Institute of Dental Research, Bethesda, Md. Dr. Cooper is an American Cancer Society Research Professor now at the University of Alabama Medical School.

Am J Dis Child. 1967;114(5):477-497. doi:10.1001/archpedi.1967.02090260065004

THE LYMPHOID SYSTEM and immunological functions are in their complete construction, late developments in phylogeny. Similarly, the development of immunologic capacities, the construction of full immunologic vigor, and the development of the normal structure of the lymphoid system are late developments in ontogeny. The lymphoid system of mature mammals and man comprises an extraordinarily complex group of cells, organs, and tissues which has been difficult to understand by direct inquiry based on classical, morphological, and experimental approaches. It is for this reason that our group in Minneapolis has been attempting to gain understanding of the relations between structure and function from inquiry which focuses from three separate directions. We have been making an intensive study of the development of the lymphoid system and immunological functions in phylogenetic as well as ontogenetic perspective and have tried to provide a focus for these analyses from the study of developmental and acquired

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