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December 1967

Neonatal Shigellosis: Report of 16 Cases and Review of the Literature

Author Affiliations

From the John A. Hartford Foundation Diarrheal Disease Study Unit, Department of Pediatrics, University of Texas Southwestern Medical School, Dallas.

Am J Dis Child. 1967;114(6):603-611. doi:10.1001/archpedi.1967.02090270059004

SHIGELLOSIS rarely affects infants during the first month of life.1-5 Even in highly endemic areas neonatal shigellosis is exceedingly uncommon.3,5 This is puzzling since newborn infants are susceptible to other enteric infections, notably enteropathogenic strains of Escherichia coli and Salmonella species. The world's literature contains reports6-12 of only eight bacteriologically confirmed cases of neonatal shigellosis (onset of disease before 28 days of life). As a consequence, little is known about the clinical manifestations and epidemiologic implications of shigellosis in this age group.

This paper summarizes the eight previously reported cases and the 16 cases seen at Children's Medical Center and Parkland Memorial Hospital in Dallas. Four cases, which developed while the infants were in the nursery, are presented in detail. Two of these infants died of peritonitis following intestinal perforation.

Four Cases With Onset in the Hospital Nursery  Case 1.—A 2,268-gm (5 lb) Negro girl was born

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