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December 1967

Elevated Serum Gonadotrophins in Silver's Syndrome

Am J Dis Child. 1967;114(6):658-661. doi:10.1001/archpedi.1967.02090270114015

IN 1953 Silver et al1 reported cases of two children having a syndrome characterized by low birth weight after full-term gestation, shortness of stature, hemihypertrophy, and elevated urinary gonadotrophins. Subsequently, Silver and various other authors have reported cases of numerous children with similar manifestations.2-5 In 1964 Silver summarized the findings in 29 examples of the syndrome.6 Reister and Scherz7 described cases of two additional patients and suggested the eponym, Silver's syndrome. In 1966 Moseley et al8 discussed the roentgen findings in these cases.

Other clinical manifestations encountered in the syndrome are as follows: variations in sexual development; short, incurved fifth fingers; triangular shaped facies; cafe au lait spots; and syndactyly. One case was associated with congenital heart disease.

The purpose of the present paper is to discuss the clinical and laboratory findings in a case of Silver's syndrome occurring in a very young child. The