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January 1968

Disseminated Herpes Simplex Virus InfectionIts Pathogenesis Based on Virological and Pathological Studies in 33 Cases

Am J Dis Child. 1968;115(1):1-8. doi:10.1001/archpedi.1968.02100010003001

THE NATURAL history of herpes simplex virus infection, which has been well established since the virus was first incriminated as a cause of stomatitis in children,1 was reviewed recently.2,3 Primary infection occurs most often in a subclinical or clinically unrecognized form in early childhood. If the primary infection is overt it may present in a variety of ways and recovery usually follows, but occasionally permanent damage or death results. The epidemiology of fatal disseminated herpes simplex virus infection occuring in children after the neonatal period has been reviewed and the association with malnutrition and measles stressed.4 Little is known about the pathogenesis of this fatal form of infection which was initially recognized in Cape Town, South Africa in 1957.5 Detailed virological and pathological studies have been carried out in 33 cases, including one neonate, seen in the subsequent nine years, and results of these studies are

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