IMIPRAMINE HYDROCHLORIDE (Tofranil) has been used since 1960 to treat the symptoms of enuresis. An unpublished review (by J. W. C.) of the research reported during 1960 to 1965 revealed 28 studies, of which only six used a control group and a large enough sample to give reliable results.1-6 All six studies showed that imipramine did reduce enuresis significantly. In comparison with those 28 studies, this is the first study to meet all the following criteria: doubleblind technique; a large sample drawn from a presumed normal population of schoolchildren; and exclusion of other therapeutic attempts (such as counseling, psychotherapy, conditioning, habit training, etc).
Twelve hundred letters were distributed among eight different grammar and high schools in Chicago and its suburbs. The letters were given to the school principals, who gave them to the teachers, who handed them to students in sealed envelopes with instructions to give them to
Miller PR, Champelli JW, Dinello FA. Imipramine in the Treatment of Enuretic Schoolchildren: A Double-Blind Study. Am J Dis Child. 1968;115(1):17–20. doi:10.1001/archpedi.1968.02100010019003
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