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January 1968

Acute Glomerulonephritis Associated With Normal Serum B1C-Globulin

Author Affiliations

Washington, DC
From the departments of pediatrics, pathology and microbiology of Georgetown University School of Medicine, Children's Hospital of DC, Arlington Hospital, Arlington, Va, and Georgetown University Hospital.

Am J Dis Child. 1968;115(1):29-36. doi:10.1001/archpedi.1968.02100010031006

THE association of acute glomerulonephritis with a previous streptococcal infection is well known.1-6 A reduction of serum hemolytic complement in various forms of nephritis has been adequately documented.7-15 Measurement of serum β1C-globulin levels have directly paralleled the serum hemolytic complement activity and, therefore, the serum β1C-globulin level may be used as an indication of the serum complement activity.11 There exists a preponderance of evidence which indicates that β1C-globulin levels are low in acute glomerulonephritis, and exceptions to this established fact have been noted only in rare instances.12,13

This report will present pertinent clinical, pathologic, and immunologic data in a group of children observed, during the winter months from 1962 to 1963 in the greater Washington, DC area,14 to have acute glomerulonephritis and in which a significant number failed to show a low β1C-globulin level.

Methods and Clinical Material  Twenty-five children with the clinical features of acute glomerulonephritis, hospitalized on the