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January 1968

Chronic Granulocytic Leukemia: Early Blast Crisis Simulating Acute Leukemia

Author Affiliations

Los Angeles
From the Department of Pediatrics, University of California School of Medicine, Los Angeles.

Am J Dis Child. 1968;115(1):66-70. doi:10.1001/archpedi.1968.02100010068013

CHRONIC GRANULOCYTIC leukemia is a relatively infrequent occurrence in the pediatric age group. The following patient is reported with the suggestion that occasional cases of this disease presenting early with a blastic crisis may be mistaken for the more common acute leukemia.

Report of a Case  A 12-year-old white girl was referred to the UCLA Medical Center on May 4, 1966 with a diagnosis of chronic granulocytic leukemia. The patient had been in good health except for slight listlessness for the preceding month. Four days prior to her visit she complained of pain in the right neck area, and noted a painful swelling below the right ear and in the right submandibular area. The swellings increased by the following day when her local physician noted marked right anterior cervical adenopathy. The white blood count was 190,000/cu mm and bone marrow examination was compatible with chronic granulocytic leukemia. Family history and