THE CAUSE of congenital heart disease is unknown except for the recognition that it may occur in certain hereditary diseases, may be associated with chromosomal abnormalities, and may be related to an intrauterine viral disease such as rubella. In the hope of finding additional etiologic factors related to congenital heart disease, a study was undertaken of the genetic and prenatal histories of 533 families of children with congenital heart disease.
The 533 family units in the study represented the family histories of children seen consecutively over a six-month period at our institution in whom a definite diagnosis of a specific cardiac lesion could be made. In addition to these children and their families, designated as the "study group," family histories were analyzed for 100 children who did not have congenital heart disease (they were seen at an outpatient facility for acute illnesses). These children and their families were designated
Feldt RH, O'Connell EJ, Stickler GB, Weidman WH. Etiologic Factors in Congenital Heart Disease: Clinical Evaluation. Am J Dis Child. 1968;115(5):552–556. doi:10.1001/archpedi.1968.02100010554004
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