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July 1968

Anaphylactoid Purpura With Massive Gastrointestinal Hemorrhage and Glomerulonephritis: An Unusual Case Treated Successfully With Azathioprine and Corticosteroids

Author Affiliations

From the McGill University-Montreal Children's Hospital Research Institute, Canada.

Am J Dis Child. 1968;116(1):97-102. doi:10.1001/archpedi.1968.02100020099015

GASTROINTESTINAL and renal manifestations occur frequently in anaphylactoid purpura. The patient reported herein exhibited certain features which merit special attention. Gastrointestinal hemorrhage was massive, requiring a phenomenal amount of blood replacement and prolonged, careful monitoring of the central venous pressure. Renal involvement was also severe leading to the development of uremia and the nephrotic syndrome; these manifestations responded dramatically to azathioprine and steroid therapy. The patient has not only survived but has regained normal health without detectable residual renal impairment.

Report of a Case  A 10-year-old girl was admitted to the Montreal Children's Hospital on May 27, 1966, complaining of abdominal pain of two day's duration. During this period, itchy red spots appeared on her abdomen and legs, the eyelids swelled, and she complained of pain in the left elbow.On initial examination her blood pressure was 160 systolic, 100 diastolic. The weight was 42 kg (92 lb 8 oz)

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