EPIDEMIOLOGICAL studies of streptococcal disease seem to suggest that the primary focus of infection lies within the family unit. Apparently streptococcal carriers and disseminators from these family units are the primary contributors to the overall community incidence of this disease. However, only a few investigators have reported specific studies designed to provide information about factors relating to intrafamilial spread of this disease agent.1-5 Some of these studies involved private or clinic patients whose families were seen only once during each illness.1,5 Other investigations were longitudinal, but principally involved private patients.2-4 Therefore, none of the family groups was selected in a manner that provided cross-sectional representation of the community. In most instances, the index case in the family, as well as individuals who subsequently showed a positive culture, were given adequate therapy which disrupted or biased natural intrafamilial spread. Finally, certain bacteriological techniques, such as M- and T-typing
Zimmerman RA, Wilson E. Familial Susceptibility to Acquisition of Group A B-Hemolytic Streptococci. Am J Dis Child. 1968;116(3):292–300. doi:10.1001/archpedi.1968.02100020294010
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