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Article
October 1968

Noonan's Syndrome: A Case With Elevated Serum Alkaline Phosphatase Levels and Malignant Schwannoma of the Left Forearm

Am J Dis Child. 1968;116(4):359-366. doi:10.1001/archpedi.1968.02100020363003
Abstract

THIS report concerns a particularly interesting patient with a complex dysmorphogenetic syndrome and an elevated level of serum alkaline phosphatase who developed a malignant schwannoma.

Report of a Case  The patient (No. 501867, born Dec 22, 1951) was first admitted to the University of Wisconsin Hospitals at the age of 5 years for dyspnea on exertion and cyanosis.The patient was delivered by caesarean section due to placenta previa after a full-term pregnancy. His birth weight was 3,345 gm (7 lb 6 ounces); his birth length is unknown. During the first year of life, he failed to gain weight satisfactorily; a cardiac murmur was first heard around the age of 12 months. He became cyanotic primarily during breath-holding spells. His penis had been noted to be large since birth.At the time of his first admission to the University Hospitals, he appeared to be a small, pale child, measuring 104

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