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October 1968


Am J Dis Child. 1968;116(4):453. doi:10.1001/archpedi.1968.02100020456025

To the Editor.—The comments by Drs. Di Toro, Ansanelli, and Lupi are most pertinent and interesting. They complement and confirm our results and we would like to express our appreciation for their comments

The effects of other pharmacologic agents on sulfobromophthalein (BSP) metabolism should be interpreted with some caution because the effect may occur at several different points in the overall scheme of BSP metabolism. We refer specifically to the recent report by Klaassen which clearly demonstrated that in adult rats pretreated with phenobarbital, a major increase in excretion and bile flow occurred which appeared to be far more important than the increase in conjugation.1