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November 1968


Author Affiliations

National Institutes of Health Bethesda, Md

Am J Dis Child. 1968;116(5):565. doi:10.1001/archpedi.1968.02100020569027

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To the Editor.—In the course of tissue culture studies on the pathogenesis of rheumatic fever, we are in need of rheumatic nodules which have recently formed in the course of rheumatic carditis. These structures have become rare due to the recent decrease in the prevalence and severity of acute rheumatic fever and the widespread use of steroids.

The nodule should be situated on the extremities, be readily accessible to biopsy, and preferably should be just in the process of forming, although nodules of any age would be welcome. Because of the possibility of confusion with other lesions, we would prefer not to have nodules of the scalp.

We would be deeply grateful to any physician or investigator who could make such tissues available. Self addressed air express containers with tissue culture fluid together with certain details concerning the technique of biopsy will be made available to those who feel

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