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Article
March 1969

Cerebral Gigantism

Author Affiliations

Denver
From the departments of pediatrics (Dr. Ott) and biophysics (Dr. Robinson), University of Colorado Medical Center, Denver.

Am J Dis Child. 1969;117(3):357-368. doi:10.1001/archpedi.1969.02100030359023
Abstract

SINCE Sotos et al1 described the syndrome of cerebral gigantism characterized by large stature, typical facies, nonprogressive neurological disorder, and mental retardation, there have been 33 cases reported.2-10 The purpose of this paper is to present an additional case report which includes some studies not previously emphasized, and to review the literature.

Report of a Case  The patient is an 11½-year-old white girl who has been evaluated annually since her fifth year because of her large stature. Following a term pregnancy complicated by hyperemesis gravidarum, vaginal bleeding, marked edema, and a difficult six-hour labor, normal deliver ensued. There were no neonatal difficulties except moderate jaundice which persisted for one month. At birth, her measurements were as follows: length, 56 cm (22½ inches) (> 97th percentile); weight, 4,423 gm (9 lb 12 ounces) (> 97th percentile); and head circumference, 40 cm (> 97th percentile).General development was within normal

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