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April 1969

Diabetes Mellitus: Incidence in Families of Children With Nephrotic Syndrome

Author Affiliations

Rochester, Minn
From the Section of Pediatrics, Mayo Clinic and Mayo Foundation and the Mayo Graduate School of Medicine (University of Minnesota), Rochester.

Am J Dis Child. 1969;117(4):442-444. doi:10.1001/archpedi.1969.02100030444010

THE PURPOSE of this study was to determine whether or not there is an increased incidence of diabetes mellitus in the families of children with nephrotic syndrome. Such a relationship has been alluded to by Dr. J. D. Crawford, Harvard Medical School, at a case presentation on Sept 20, 1965 while visiting our institution, but so far no data have been published. Furthermore, a possible association was suggested by the observation of two patients in whom nephrotic syndrome occurred early in the course of diabetes mellitus but without the histologic lesions of Kimmelstiel-Wilson nephropathy.

Materials and Methods  Patients.—One hundred twenty-five children with nephrotic syndrome seen at the Mayo Clinic in the years 1953 through 1962 were used as the study probands. The mean age of these children was 5 years at the time of their initial visit. All of them were of Caucasian extraction except one Chinese boy.For

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