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June 1969

Carbonic Anhydrase Inhibitors in Chronic Infantile Hydrocephalus

Author Affiliations

From the Nebraska Psychiatric Institute and the University of Nebraska College of Medicine, Omaha. Dr. Schain is now with the Division of Pediatrics, UCLA Center for the Health Sciences, Los Angeles.

Am J Dis Child. 1969;117(6):621-625. doi:10.1001/archpedi.1969.02100030623002

The CHILD with slowly progressive hydrocephalus who is judged not to be suitable for neurosurgical treatment is still a common neuropediatric problem. The decision to withhold surgery may be based upon advanced hydrocephalus present at birth, the presence of associated somatic defects, or the lack of neurosurgical facilities. These children, in spite of advanced hydrocephalus, may demonstrate only minimal neurological abnormalities during the first years of life. The major disability of the infant is often only the mechanical problem of supporting the enlarged head. Ultimately a variety of disabilities become evident including visual defects, cerebellar ataxia, spastic diplegia, and mental retardation.1-3 An interesting special personality type characterized by excessive verbosity and inappropriate sociability (the cocktail party syndrome) has been considered as typical of hydrocephalic children during later development.4

The many difficulties associated with the surgical approaches available for the treatment of hydrocephalus have stimulated efforts for medical therapy

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