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June 1969

Treatment of Streptococcal Infection With Sulfamethoxazole and Penicillin: Bacteriological and Immunological Response

Author Affiliations

From the Department of Pediatrics, University of Colorado School of Medicine, Denver.

Am J Dis Child. 1969;117(6):663-667. doi:10.1001/archpedi.1969.02100030665007

ALTHOUGH sulfonamides are considered effective in preventing streptococcal infections, early studies led to the conclusion that they are ineffective when given after an infection has developed.1 Recently, claims have been made that sulfamethoxazole, if given for ten days, is effective both in eradicating streptococcal infection as judged by repeat cultures2 and in suppressing a rise in antistreptolysin (ASO) titers, according to a written communication from Roche Laboratory in November 1966. However, there is still controversy on the latter point,3 and controlled studies are lacking. The present study was designed to investigate the comparative effects of sulfamethoxazole and penicillin in preventing ASO titer rise and in abolishing group A streptococci from throat cultures.

Materials and Methods  Subjects.—Subjects of this investigation came from the group of patients who attended the pediatric clinic of the University of Colorado Medical Center in the spring of 1967 during the hours the