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June 1969

Screening Method for Determining Glucose in Blood and Cerebrospinal Fluid

Author Affiliations

From the Departments of Pediatrics (Miss Luebben, and Drs. Cornblath and Swiatek) and Biological Chemistry (Dr. Swiatek), University of Illinois College of Medicine, and the Illinois State Pediatric Institute (Dr. Swiatek), Chicago. Dr. Cornblath is now with the Department of Pediatrics, University of Maryland, School of Medicine, Baltimore.

Am J Dis Child. 1969;117(6):672-677. doi:10.1001/archpedi.1969.02100030674009

THE PURPOSE of this paper is to report a modification of the standard reagent strip (Dextrostix) technique which distinguishes between glucose values in plasma and cerebrospinal fluid (CSF) of 40, 30, 20, and less than 20 mg per 100 ml. The method is simple, reliable, and produces a permanent color change.

The method is suitable as a screening tool to detect low glucose concentrations in blood of term and low birth weight infants,1 infants of diabetic mothers in whom transient hypoglycemia occurs the first two to six hours of life,2 as well as to detect low glucose levels in CSF of infants with possible meningitis. Furthermore, the effectiveness of therapy in elevating glucose levels can be easily and inexpensively monitored using the modified reagent strip technique.

Material and Methods  Blood was drawn by heel puncture from 83 infants in the nurseries at the University of Illinois Research and

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