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August 1969

Live Rubella Virus Vaccin n Tuberculous Children

Author Affiliations

Brooklyn, NY
From the Department of Pediatrics, State University of New York, Downstate Medical Center, Brooklyn, NY. Dr. Berkovich is a Career Scientist of the Health Research Council of the city of New York under contract No. I-173.

Am J Dis Child. 1969;118(2):252-257. doi:10.1001/archpedi.1969.02100040254018

RUBEOLA is known to cause depression of tuberculin skin reactivity and to exert a deleterious effect on the clinical course of untreated, childhood tuberculosis.1,2 The live, attenuated measles virus vaccine has also been shown to depress skin reactivity and possibly to affect adversely the clinical status of the unrecognized tuberculous child.1,3,4

Since rubella and rubeola are both exanthematous, viral diseases, it is understandable that the live, attenuated rubella virus vaccine might be suspected of effects similar to those related to the measles vaccine. It is desirable, therefore, that the safety of the rubella product be established for the tuberculous individual before its widespread distribution for clinical use.

The present report describes our experience with 18 hospitalized children under treatment for tuberculosis who were inoculated with the Cendehill strain of attenuated rubella virus.

Materials and Methods  Study Outline.—The study group was composed of 24 tuberculous children ranging in

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