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August 1969

Clinical Experience With Cendehill Rubella Vaccine in Mature Women

Author Affiliations

Philadelphia; San Juan, PR
From the Presbyterian-University of Pennsylvania, Medical Center, Philadelphia (Dr. Farquhar), and the Humacao Health Center, San Juan, PR (Dr. Corretjer).

Am J Dis Child. 1969;118(2):266-268. doi:10.1001/archpedi.1969.02100040268023

RECENTLY reported experience1 with live attenuated rubella vaccines suggested that all of the vaccines currently under investigation elicit approximately the same hemagglutination inhibiting (HI) antibody response and none produce any significant clinical reactions in children. However, when used in rubella-susceptible mature women, the high risk population for rubella, the vaccines appeared to differ in the incidence and degree of associated side effects.2-4 The HPV-77 rubella vaccine and its modifications grown in duck embryo and dog kidney cultures caused the signs and symptoms of a natural rubella infection in a high percentage of mature women vaccinees. The most troublesome of these side effects was arthralgia or arthritis.5 In contrast, the Cendehill rubella vaccine seemed to cause a minimum of side effects in adult vaccinees.2-6

Our present studies were undertaken to determine the incidence and severity of side effects with the Cendehill rubella vaccine in a significant