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September 1969

Congenital Cytomegalovirus Infection Associated With Multicystic Kidney

Author Affiliations

From the Department of Pediatrics, University of Pennsylvania, Children's Hospital of Philadelphia, and the Wistar Institute of Anatomy and Biology (Dr. Plotkin), and the Children's Hospital of Philadelphia (Dr. Pasquariello).

Am J Dis Child. 1969;118(3):515-517. doi:10.1001/archpedi.1969.02100040517018

THE SPECTRUM of disease caused by congenital cytomegalovirus infection is gradually being expanded beyond the classic combination of hepatosplenomegaly, thrombocytopenia, and microcephaly.1 Milder forms of congenital infection have been described,2-4 and it is possible that some infants born infected will be totally asymptomatic. Recent surveys indicate that 1% to 2% of ostensibly normal infants carry cytomegalovirus at birth.5 Since follow-up studies of these infected but asymptomatic infants have not yet been reported, the pathogenicity of the virus in these cases is uncertain.

The case report that follows concerns a newborn infant with undoubted cytomegalovirus infection, who also had a cystic horseshoe kidney. Speculation concerning the relationship of the two findings is presented.

Report of a Case  The patient is a male first-born child. No unusual incidents or minor illnesses occurred during the pregnancy of his mother who was 32 years of age. Labor and delivery were normal.

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