IN 1960, Holtermueller and Wiedemann1 described a new case of cloverleaf skull and reviewed the literature. They named the entity the Kleeblattschädel syndrome. Comings2 and Angle et al3 subsequently described the only three reported cases in the American literature.
The major diagnostic features of this syndrome include a grotesque, trilobed skull resulting from congenital premature synostosis of the coronal and lambdoidal sutures (plus other sutures as described in our patients); severe exophthalmos; deformities of the long bones resembling achondroplasia; mental retardation; and an early demise.1-5
Two new cases of the Kleeblattschädel syndrome are reported. The first a 14-year-old girl, is the oldest recorded patient, and the second represents the typical long bone changes.
Report of Cases
Case 1.—The first patient, a 14-year-old white girl, was the product of a 33-year-old, gravida 4, para 2, abortus 2 mother and a 34-year-old father. The pregnancy was not complicated
Feingold M, O'Connor JF, Berkman M, Darling DB. Kleeblattschädel Syndrome. Am J Dis Child. 1969;118(4):589–594. doi:10.1001/archpedi.1969.02100040591011
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