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October 1969

Sickle Cell Disease and Acute Glomerulonephritis

Author Affiliations

From the Division of Clinical Hematology, the departments of medicine (Dr. Susmano) and pediatrics (Dr. Lewy), Michael Reese Hospital and Medical Center, Chicago. Dr. Susmano is a research fellow of the Division of Clinical Hematology.

Am J Dis Child. 1969;118(4):615-618. doi:10.1001/archpedi.1969.02100040617015

HEMATURIA is a well recognized occurrence in the course of sickle cell trait and anemia. Since hematuria occurs with relatively high frequency,1-5 other causes of hematuria are often overlooked in patients who exhibit sickling. Two cases of acute glomerulonephritis in children with type S hemoglobin are presented to illustrate the concurrence of these diseases.

Report of Cases  Case 1.—A 2 year 5 month-old Negro boy was well until three weeks prior to admission, when he suffered multiple mosquito bites, several of which became infected. For the four days prior to admission, decreased urination, increased weight, and edema were noted. Physical examination on admission revealed an acutely ill child with a temperature of 102 F (38.9 C); blood pressure, 120/90 mm Hg; pulse rate, 140 beats per minute, and respiration rate, 50 breaths per minute. There was generalized edema involving his face, abdomen, presacral area, hands, and legs. Eye grounds

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