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December 1969

Maternal Phenylketonuria: Detrimental Effects on Embryogenesis and Fetal Development

Author Affiliations

From the Department of Pediatrics (Drs. Fisch and Anderson and Miss Doeden) and the Division of Neurology (Dr. Lansky), University of Minnesota, Minneapolis.

Am J Dis Child. 1969;118(6):847-858. doi:10.1001/archpedi.1969.02100040849007

Maternal phenylketonuria is likely to have damaging effects on the offspring. Intrauterine growth retardation, postnatal growth retardation, microcephaly, mental retardation, congenital malformations in the infant, and spontaneous abortions in the mother suggest the possibility of maternal phenylketonuria even if the mother is of normal intelligence.

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