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January 1970

C-Group Chromosome Abnormality (? 10p-): Occurrence in a Child With Multiple Malformations

Author Affiliations

From the departments of pediatrics (Drs. Elliott, Thomas, Condron, and Richardson) and pathology (Dr. Khuri), The John F. Kennedy Institute, The Johns Hopkins University School of Medicine, Baltimore.

Am J Dis Child. 1970;119(1):72-73. doi:10.1001/archpedi.1970.02100050074017

Observations in the form of case reports combined with detailed chromosome analyses have been responsible in recent years for the delineation of several chromosomal deletion syndromes.1-3 It is for this reason that we should like to report an instance of a partial deletion of a C-group chromosome which, in accordance with the nomenclature of the Chicago Conference,4 would be designated 46,XX,? 10p—.

Report of a Case  This female Negro infant, birth weight 1,780 gm (4 lb 1¼ ounces), length 43 cm (1 ft 5 inches), head circumference 25.5 cm, chest circumference 26.5 cm, was delivered at the 35th week of gestation by frank breech, following premature rupture of the membranes (Fig 1).A single umbilical artery was noticed at initial examination. The skull was narrow with a prominent occiput, shallow orbits, periorbital edema, depressed nasal bridge, wide everted nostrils, and elongation of the philtrum. There was an auricular

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