The occurrence of rose spots in patients with typhoid and paratyphoid fevers has been known for over half a century.1-3 Rose spots are round, red, slightly raised, smooth-edged skin lesions which measure 1 mm to 4 mm in size and blanch on pressure. They develop in the corium and consist of dilated lymphatics and small blood vessels surrounded by a perivascular infiltrate of polymorphonuclear cells, lymphocytes, mast cells, plasma cells, and fibroblasts.4 Cultures of rose spots from patients with typhoid fever may yield Salmonella typhi.2,4
Little information is available regarding the presence of rose spots in other diseases. They have been described in patients with psittacosis,5 leptospirosis,5 trichinosis,3 brucellosis,6 miliary tuberculosis,2,3 and meningitis.2
The present communication reports the development of rose spots in three siblings with dysentery due to Shigella flexneri 4a. One week before these children became ill the family
Goscienski PJ, Haltalin KC. Rose Spots Associated With Shigellosis. Am J Dis Child. 1970;119(2):152–154. doi:10.1001/archpedi.1970.02100050154014
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