The uncommon clinical syndrome of sexual precocity, polyostotic fibrous dysplasia, and cutaneous pigmentation was first described by Mc-Cune1 and Albright et al.2 The sexual precocity has been ascribed to premature activation of the normal mechanisms initiating puberty,3 although ovulation in the chronologically prepubertal female subject with McCune-Albright's syndrome has never been demonstrated. Spermatogenesis before the normal age of puberty has been reported in a single case.4 We report a further case of McCune-Albright's syndrome in which the excretion of urinary estriol was unusually high as were serum growth hormone levels following insulin induced hypoglycemia. The excretion of urinary luteinizing hormone by a radioimmunoassay method5 was also measured.
Report of a Case
First Admission.—The patient, a 9-year-old girl, was first admitted to hospital aged 3 months because of vomiting and vaginal bleeding. At laparotomy, an infarcted right ovary, thought to be secondary to torsion of
Husband P, Snodgrass GJAI. McCune-Albright Syndrome With Endocrinological InvestigationsReport of a Case. Am J Dis Child. 1970;119(2):164–167. doi:10.1001/archpedi.1970.02100050166017
Customize your JAMA Network experience by selecting one or more topics from the list below.