Among 191 patients with facial clefts (cleft lip and/or cleft palate), the incidence of congenital heart defects was increased. Two-thirds (21 of 32) of the dead children had severe heart disease. In 150 living patients with facial clefts, the incidence of congenital cardiac malformations was 1.3%. In the 31 patients concordant for facial clefts and heart disease, transposition of the great vessels and single ventricle were unexpectedly absent, probably because the embryological defect responsible for these two cardiac lesions precedes palatal development by 1½ to 2 weeks. The incidence of heart disease, while high (20%) in children dying with the Pierre Robin syndrome, was greater (75%) in deceased infants who had cleft palate without the Pierre Robin syndrome.
Shah CV, Pruzansky S, Harris WS. Cardiac Malformations With Facial Clefts: With Observations on the Pierre Robin Syndrome. Am J Dis Child. 1970;119(3):238–244. doi:10.1001/archpedi.1970.02100050240010
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