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April 1970

Gamma-Globulin Synthesis in the First Month of Life

Author Affiliations

From the Child Research Council, Department of Pediatrics, University of Colorado School of Medicine, Denver.

Am J Dis Child. 1970;119(4):296-297. doi:10.1001/archpedi.1970.02100050298002

The newborn infant is well endowed with IgG received largely, or entirely, by placental transfer from his mother. Fudenberg1 and Hunger and Thierbach2 have suggested that the human fetus is capable of some synthesis of IgG, possibly only under unusual circumstances. van Furth et al3 have shown that spleen cells from fetuses born after 20 weeks gestation are capable of producing IgG. This situation may also be considered unusual and may or may not indicate the conditions which prevail in normal fetal development. The general opinion as expressed by others has been that active synthesis does not begin until some time after birth. Allansmith et al4 suggest that synthesis begins after two weeks. Rosen and Janeway5 believe that synthesis does not begin until the end of the second month, and support this view by stating that plasma cells do not appear until the third month