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April 1970

Distichiasis-Lymphedema: A Hereditary Syndrome of Multiple Congenital Defects

Author Affiliations

Yellow Springs and Dayton, Ohio
From the Birth Defects Evaluation Clinic (Dr. Robinow), and the departments of radiology (Dr. Johnson) and surgery (Dr. Verhagen), Yellow Springs Clinic, Yellow Springs, Ohio, and the Barney Children's Medical Center, Dayton, Ohio.

Am J Dis Child. 1970;119(4):343-347. doi:10.1001/archpedi.1970.02100050345013

In 1964, Falls and Kertesz1 described a family in which ten members in five generations showed a new syndrome consisting of distichiasis (extra rows of eyelashes) regularly combined with lymphedema of the lower extremities and sometimes associated with webbed neck and partial ectropion of the lower lids.2 Their report included an additional family with a sporadic case. Recently, three new families exhibiting this syndrome have come to our attention. Chynn3 described two siblings suffering from extradural cysts but made only a casual reference to the associated distichiasis and lymphedema. A more extensive pedigree of this family was later published by Bergland.4 Additional details concerning these patients were given to us by Simpson and German (written communication, Jan 14, 1969). (A less complete pedigree of the same family was published earlier by Neel and Schull.2) Information on another large kindred was supplied by S. R. Thompson,