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May 1970

Hepatic Cell Necrosis in the Newborn: A Pathologic Study of 147 Cases, With Particular Reference to Congenital Heart Disease

Author Affiliations

Los Angeles
From the Department of Pathology, Childrens Hospital of Los Angeles, and University of Southern California School of Medicine, Los Angeles.

Am J Dis Child. 1970;119(5):395-400. doi:10.1001/archpedi.1970.02100050397003

One hundred and forty-seven infants who died from birth to 7 days of age were studied for the relation of hepatic cell necrosis to other pathological conditions. Disseminated hepatic necrosis was significantly correlated with congenital heart disease, and hypoplastic left heart complex and coarctation of the aorta were more frequently associated with disseminated hepatic necrosis than were other types of congenital heart disease. The microscopic features of the liver in these types of congenital heart disease are not those of congestive heart failure, and the hepatic changes observed are considered more probably due to decreased arterial blood flow than to passive venous congestion. Localized hepatic necrosis was significantly correlated with gastroschisis, omphalocele, or diaphragmatic hernia, and hemorrhage in portal areas was associated with the presence of intracranial hemorrhage.