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July 1970


Am J Dis Child. 1970;120(1):89. doi:10.1001/archpedi.1970.02100060123028

To the Editor.—The report in the January 1970 issue (Amer J Dis Child119:68-71) by Glick et al outlines another association for Reye's syndrome. As the authors note in their comments, these two cases contribute to the evidence that a number of viruses may be involved in the etiology of Reye's syndrome.

In the summer of 1962, in North Carolina, an unusual number of severe encephalitis cases occurred. This was before the publication of

Reye's original cases. The syndrome was uniform and consisted of a mild influenza-like illness followed by one or two days of apparent recovery and then sudden, overwhelming encephalopathy with death in 24 to 36 hours in most cases. Several of these children were noted to have what appeared to be an acute yellow atrophy of the liver. In most of the cases reported by us in the North Carolina Medical Journal,1 pathologic findings