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August 1970

Reed-Sternberg Cells in Infectious Mononucleosis: Report of a Case

Author Affiliations

Duarte and Loma Linda, Calif
From the departments of anatomic pathology (Drs. McMahon and Gordon) and pediatrics (Dr. Rosen), City of Hope Medical Center, Duarte, Calif; and the Department of Pathology, Loma Linda University, Loma Linda, Calif (Dr. Gor-; don).

Am J Dis Child. 1970;120(2):148-150. doi:10.1001/archpedi.1970.02100070092012

A 4½-year-old boy experienced the acute onset of fever, generalized lymphandenopathy, apparent respiratory obstruction, and hepatosplenomegaly. Laboratory studies were compatible with infectious mononucleosis. In order to rule out the possibility of a fulminant lymphoma and govern the therapy, a cervical lymph node biopsy was performed. Histological examination revealed architectural distortion and engorgement with atypical reticulum cells, some of which were indistinguishable from Reed-Sternberg cells. However, an interpretation of Hodgkin's disease was deferred, and the patient was treated conservatively. Thirteen months later he was asymptomatic, and his abnormal physical findings and laboratory tests returned to normal. This patient is presented, therefore, as an instance of the presence of Reed-Sternberg cells in a disease other than Hodgkin's.

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