A 10-year-old boy developed acute uric acid nephropathy consequent on treatment of a lymphoblastic lymphosarcoma. Treatment resulting in rapid lysis of malignant cells causes a rise of serum uric acid levels and an increased urinary acid load which may precipitate acute renal failure in kidneys already damaged by the effects of hyperuricemia of the malignancy per se. Clinical foresight and appropriate prophylactic therapy in similar cases are recommended.
Passwell J, Boichis H, Cohen BE. Hyperuricemic Nephropathy: Report of a Case of Lymphoblastic Lymphosarcoma. Am J Dis Child. 1970;120(2):154–156. doi:10.1001/archpedi.1970.02100070098014
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