Endocrine manifestations of neurofibromatosis have been reported in five children, and the literature has been reviewed. Children often show disorders of sexual development and growth, while pheochromocytoma is the commonest endocrine association in adults. Precocious sex development was noted in three children. Two other girls presented with marked retardation of growth. One of them had retarded sex development in association with anorexia nervosa. It has been emphasized that such manifestations may frequently be the presenting features of neurofibromatosis in children.
Saxena KM. Endocrine Manifestations of Neurofibromatosis in Children. Am J Dis Child. 1970;120(3):265–271. doi:10.1001/archpedi.1970.02100080149020
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: