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November 1970

Possible Mechanisms for Maintaining Immunity to Varicella-Zoster Virus: Clinical Observations

Author Affiliations

New York; Bayonne, NJ; New York
From the departments of dermatology (Dr. Gibbs) and pediatrics (Dr. Brunell), New York University Medical Center, New York, and the departments of dermatology (Dr. Shapiro) and pediatrics (Dr. Cassidy), Bayonne Hospital and Dispensary, Bayonne, NJ.

Am J Dis Child. 1970;120(5):456-457. doi:10.1001/archpedi.1970.02100100120015

A woman developed zoster one month following the birth of twins. Although the twins were not infected, their 4-year-old sibling developed varicella following exposure to their mother. The twins were probably protected against varicella by maternal antibody. It would appear, therefore, that the rate of maternal antibody synthesis at delivery was adequate to protect the twins against exogenous infection but it was not adequate to neutralize activated latent varicella-zoster virus and prevent the occurrence of maternal zoster.

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